SHM's Clinical Quick Talks-Abnormal Liver Function Tests (LFTs)

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The document provides an overview of abnormal liver function tests (LFTs), categorizing them into hepatocellular and cholestatic injuries based on enzyme elevations. Differentiating between these injuries can be done using the R factor. Elevated AST and ALT suggest liver damage, while high ALP indicates biliary issues. Various causes for elevated enzymes are highlighted, such as NAFLD, hepatitis, and cirrhosis. Elevated bilirubin levels can lead to jaundice and pruritus, with different types of hyperbilirubinemia mentioned. Clinical pearls include common causes of severely elevated AST/ALT, prognostic factors in drug-induced liver injury, and autoimmune markers for hepatitis diagnosis. The document also emphasizes the importance of interpreting liver function markers. Differentiation between liver and bone diseases related to ALP elevation is discussed, along with the diagnostic approach for various biliary system disorders. Lastly, references are provided for further reading on liver function tests.

Asset Subtitle

Garrett Chan, Hely Shah

Meta Tag

Concept Hepatocellular Injury

Concept Cholestatic Injury

Concept Hyperbilirubinemia

Concept AST

Concept ALT

Keywords

abnormal liver function tests

hepatocellular injury

cholestatic injury

R factor

NAFLD

hepatitis

cirrhosis

bilirubin levels

jaundice

pruritus

Hepatocellular Injury

Cholestatic Injury

Hyperbilirubinemia

AST

ALT