SHM Converge Scientific Abstract ePoster Gallery-Vaccination Impact on Utility of Known Risk-Factors for Severe Covid-19

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This retrospective cohort study examined 2,960 adult patients hospitalized with COVID-19 from May 2021 to June 2022 at a large urban academic hospital to assess how vaccination status affects the predictive value of known risk factors for severe disease. Severe COVID-19 was defined as ICU admission or escalation to ICU care at any point during hospitalization, or in-hospital death. Researchers analyzed demographics, comorbidities, vaccination status, and CHA2DS2-VASc scores using multivariate analysis.<br /><br />The patient population was 44.8% female, 76.8% Black, and 27.1% had chronic kidney disease (CKD). In multivariate analysis, race, obesity, CKD, CHA2DS2-VASc score, and vaccination status were identified as key factors associated with severe COVID-19 infection. Among these, vaccination status was the strongest predictor of severity (OR 1.51, 95% CI 1.25–1.82), followed by CKD (OR 1.33, 95% CI 1.08–1.63).<br /><br />The study concludes that once vaccination status is included in risk assessment, many of the traditional predictors of COVID-19 severity are less informative. Vaccination status and CKD remain the most important predictors of severe illness, suggesting that vaccination has substantially changed the utility of earlier COVID-19 risk stratification tools.

Asset Subtitle

Tatvam T. Choksi

Meta Tag

Author List Hui Zhang, Matthew T. Cerasale, Tatvam T. Choksi

Category Research

Concept Vaccination Status

Concept Chronic Kidney Disease

Concept Severe COVID-19

Concept Predictive Value

Concept CHA2DS2-VASc Score

Distinguished Non-Finalist

Presenter Organization University of Chicago Medical Center

Presenting Author Tatvam T. Choksi

Track Outcomes Research

Keywords

COVID-19

vaccination status

severe disease

retrospective cohort study

chronic kidney disease

risk factors

ICU admission

multivariate analysis

CHA2DS2-VASc score

hospitalized patients

Vaccination Status

Chronic Kidney Disease

Severe COVID-19

Predictive Value

CHA2DS2-VASc Score