SHM Converge Scientific Abstract ePoster Gallery-Trends of Ceruloplasmin Levels in Adult Hospitalized Patients

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This retrospective study reviewed all serum ceruloplasmin tests ordered at the University of Mississippi Medical Center from 2013 to 2021. Ceruloplasmin is a liver-produced copper-carrying protein and an acute-phase reactant with clinical relevance in Wilson disease and iron metabolism, but there is limited data on how often levels are abnormal in hospitalized adults.<br /><br />Using de-identified EPIC data, the authors analyzed 1,491 ceruloplasmin tests performed on 1,483 unique adult patients. Testing increased slightly over time, with a median patient age of 51. Overall, 23.4% of tests returned at the lower cutoff value of 15.0 mcg/mL, while 10.5% were above the upper limit of 30.0 mcg/mL.<br /><br />Low ceruloplasmin was more common in males than females (20.6% vs 26.6% low in females), and elevated levels were much more frequent in males (16.9% vs 3.1% in females). By race, low levels were more common in Caucasians than African Americans (26.8% vs 18.4%), while elevated levels were more common in African Americans (14.4% vs 7.5% in Caucasians). Among patients who died by the end of the study period, low ceruloplasmin was present in 29.5% and elevated levels in 8.8%.<br /><br />The authors conclude that abnormal ceruloplasmin values are common in hospitalized adults, especially low values, and appear more prevalent in males and Caucasians. They note that these findings may not reflect the general population but suggest the need for larger and more detailed studies.

Asset Subtitle

Pradeep Bathina

Meta Tag

Author List Pradeep Bathina

Category Research

Concept Serum Ceruloplasmin

Concept Copper Transport

Concept Iron Metabolism

Concept Ferroxidase

Concept Wilson Disease

Distinguished Non-Finalist

Presenter Organization University of Mississippi Medical Center

Presenting Author Pradeep Bathina

Track Outcomes Research

Keywords

ceruloplasmin

hospitalized adults

Wilson disease

retrospective study

serum tests

acute-phase reactant

copper metabolism

abnormal laboratory values

gender differences

racial differences

Serum Ceruloplasmin

Copper Transport

Iron Metabolism

Ferroxidase

Wilson Disease