SHM Converge Scientific Abstract ePoster Gallery-Therapeutic Hypothermia Is Associated With a Decrease in All-Cause Mortality in Cardiac Arrest Due to Shockable Rhythm

Therapeutic Hypothermia Is Associated With a Decrease in All-Cause Mortality in Cardiac Arrest Due to Shockable Rhythm

Pdf Summary

This poster reports a meta-analysis evaluating therapeutic hypothermia (TH) after cardiac arrest. The authors reviewed electronic databases through September 21, 2021 and included 10 randomized controlled trials comparing TH (32–34°C) with control strategies such as normothermia or 36°C target temperature management in comatose post-cardiac arrest patients.<br /><br />A total of 3,988 patients were analyzed: 1,999 received TH and 1,989 were controls. Overall, TH did not show a statistically significant reduction in all-cause mortality compared with control (OR 0.83, 95% CI 0.66–1.05; p=0.08), and it also did not significantly improve neurological outcomes overall (OR 0.78, 95% CI 0.61–1.01; p=0.07).<br /><br />However, subgroup analysis based on initial cardiac rhythm showed a different pattern. In patients with a shockable rhythm, TH was associated with significantly lower mortality (OR 0.55, 95% CI 0.37–0.80) and better neurological outcomes (OR 0.48, 95% CI 0.32–0.72). In contrast, no meaningful benefit was seen in patients with a non-shockable rhythm.<br /><br />The background notes that cardiac arrest survivors are at high risk of death and hypoxic-anoxic brain injury, and that guidelines recommend targeted temperature management, but clinical evidence has been mixed. The conclusion is that therapeutic hypothermia appears beneficial in cardiac arrest patients with shockable rhythms, but not in those with non-shockable rhythms.

Asset Subtitle

Shivaraj Nagalli

Meta Tag

Author List Keerat Rai Ahuja, Shivaraj Nagalli, Tayyab Ali Waheed, Usama Nasir

Category Research

Concept Targeted Temperature Management

Concept Cardiac Arrest

Concept Survival

Concept Neurologic Outcome

Concept All-Cause Mortality

Distinguished Non-Finalist

Presenter Organization Brookwood Baptist Health

Presenting Author Shivaraj Nagalli

Track Outcomes Research

Keywords

therapeutic hypothermia

cardiac arrest

meta-analysis

randomized controlled trials

targeted temperature management

shockable rhythm

non-shockable rhythm

mortality

neurological outcomes

comatose patients

Targeted Temperature Management

Cardiac Arrest

Survival

Neurologic Outcome

All-Cause Mortality