SHM Converge Scientific Abstract ePoster Gallery-Therapeutic Drugs and Their Deadly Consequences: Exploring Adverse Effects-Related Mortality in the U.S. Using the CDC Wonder Database (1999-2020)

Therapeutic Drugs and Their Deadly Consequences: Exploring Adverse Effects-Related Mortality in the U.S. Using the CDC Wonder Database (1999-2020)

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This study examined deaths in U.S. adults aged 25 and older caused by adverse effects of therapeutic drugs from 1999 to 2020, using CDC WONDER death certificate data and ICD-10 codes Y40–Y59. It analyzed age-adjusted mortality rates (AAMRs) and trends by sex, race/ethnicity, region, and urban/rural status using Joinpoint regression.<br /><br />A total of 116,468 deaths were attributed to therapeutic drug adverse effects during the study period. Most deaths occurred in medical facilities (79.2%) or at home (10.43%). Overall mortality declined from 28.96 per 1,000,000 in 1999 to 23.87 in 2020, showing a significant downward trend. However, the decline was not uniform across groups.<br /><br />Men had higher mortality than women, and their mortality increased more steeply over time. Racial disparities were also evident: American Indians or Alaska Natives had the highest AAMR, followed by White, Black, Hispanic, and Asian/Pacific Islander populations. Hispanics showed the largest decline over time. Regionally, the Western U.S. had the highest mortality, and Vermont had the highest state-level rate while Massachusetts had the lowest. Nonmetropolitan areas had higher mortality than metropolitan areas, though both declined over time.<br /><br />The authors conclude that although deaths from therapeutic drug adverse effects have generally decreased, important disparities remain. They recommend better prescribing practices, stronger pharmacovigilance, and targeted prevention efforts for high-risk groups, especially men, American Indians, and residents of nonmetropolitan and western areas.

Asset Subtitle

Faiza Khalifa

Meta Tag

Author List Adnan Bhat, Atul Kapoor, Ayesha Bhat, Faiza Khalifa, Faizan Ahmed, Farman Ali, Hritvik Jain, Husnain Ahmad, Jaymin G. Patel, John N. George, John W. Merriman III, Kainat Aman, Muhammad Hunain, Mushood Ahmed, Naveen Baskaran, Nisar Asmi, Riley G. Jone

Category Research

Concept Medication Adverse Reaction

Concept Mortality

Concept Age-Adjusted Mortality Rate

Concept Average Annual Percent Change

Concept Epidemiology

Distinguished Non-Finalist

Presenter Organization University of Florida

Presenting Author Faiza Khalifa

Track Patient Safety

Keywords

therapeutic drug adverse effects

mortality trends

age-adjusted mortality rate

CDC WONDER

ICD-10 Y40-Y59

drug-related deaths

health disparities

sex differences

racial disparities

urban rural mortality

Medication Adverse Reaction

Mortality

Age-Adjusted Mortality Rate

Average Annual Percent Change

Epidemiology