SHM Converge Scientific Abstract ePoster Gallery-Safety of Laa Closure by Minimally Invasive Procedure vs Oacs in Patients With Atrial Fibrillation

Safety of Laa Closure by Minimally Invasive Procedure vs Oacs in Patients With Atrial Fibrillation - An Umbrella Meta-Analysis

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Pdf Summary

This umbrella meta-analysis evaluated the safety and effectiveness of minimally invasive left atrial appendage (LAA) closure devices, specifically Watchman and Amulet, compared with oral anticoagulants (OACs) in patients with non-valvular atrial fibrillation. The review followed PRISMA methods and used published meta-analyses identified through PubMed. Outcomes of interest included mortality, stroke, and bleeding, and pooled odds ratios were calculated using a random-effects model.<br /><br />Nineteen studies were included, with 12 providing usable outcome data. Overall, LAA closure was associated with better safety and clinical outcomes than OACs. The devices showed a significant reduction in mortality, including all-cause mortality and cardiovascular mortality. Specifically, pooled results suggested lower odds of death with LAA closure. Major bleeding was also significantly reduced compared with anticoagulant therapy. The risk of stroke was lower as well, though this finding was less definitive and showed considerable heterogeneity.<br /><br />The analysis found that Watchman and Amulet devices may offer a safer alternative to oral anticoagulation in selected atrial fibrillation patients. However, the authors noted that the evidence has moderate risk of bias and that more prospective studies and clinical trials are needed. Future research should help identify which patient groups benefit most from minimally invasive LAA closure and improve risk stratification for treatment selection.

Asset Subtitle

Tarun Parvataneni

Meta Tag

Author List Arjun Gandhi, Bhavya Raja Gopal Yarlagadda, Keerthi Sripathi, Mahmoud Aboukhreis, Parth Shah, Rutvij Patel, Sharanya Rajgopal, Sireesha Matta Vemuri Reddy, Sudha Dirisanala, Tarun Parvataneni, Urvish Patel, Venkata Harshabhargav

Category Research

Concept Umbrella Meta-Analysis

Concept Left Atrial Appendage Closure

Concept Oral Anticoagulant

Concept Non-valvular Atrial Fibrillation

Concept Mortality

Distinguished Non-Finalist

Presenter Organization Department of Family Medicine, Aiken Regional Medical Center, SC, USA

Presenting Author Tarun Parvataneni

Track Patient Safety

Keywords

left atrial appendage closure

Watchman

Amulet

oral anticoagulants

atrial fibrillation

stroke prevention

major bleeding

mortality reduction

meta-analysis

minimally invasive devices

Umbrella Meta-Analysis

Left Atrial Appendage Closure

Oral Anticoagulant

Non-valvular Atrial Fibrillation

Mortality