SHM Converge Scientific Abstract ePoster Gallery-Risk Factors Associated With Venous Thromboembolism in Patients With Liver Disease

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This study examined risk factors for venous thromboembolism (VTE) in patients with liver disease by comparing 426 liver disease patients with VTE to 859 without VTE. Patients on chronic anticoagulation or with a history of coagulopathy were excluded.<br /><br />The analysis found that patients who developed VTE were older and more likely to be female. Certain lab abnormalities were associated with VTE, including higher creatinine, lower sodium, lower platelet count, elevated INR, elevated bilirubin, and higher MELD-Na and AST values. However, several markers of more advanced liver dysfunction, such as higher bilirubin and lower sodium, were more common in the non-VTE group, suggesting that severe liver disease itself may be somewhat protective against VTE.<br /><br />Hospital complications associated with VTE included acute kidney injury and sepsis. Hepatic encephalopathy was more common in patients without VTE.<br /><br />Past medical history showed strong associations between VTE and malignancy, hypertension, atrial fibrillation, heart failure, end-stage renal disease, and autoimmune disease. In contrast, alcohol use and smoking history were more common in patients without VTE.<br /><br />Medication use showed a small difference, with proton pump inhibitor use slightly more common in the non-VTE group; NSAID and corticosteroid use were not significantly associated.<br /><br />Overall, the findings suggest that patients with stable liver disease who also have traditional VTE risk factors may be at increased risk and should be considered for VTE assessment and prevention. The authors recommend future prospective studies to clarify causality and guide personalized thromboprophylaxis strategies.

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Parker Meeks

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Author List Abdallah Hassan, Alexander S. Malayev, Andrew Hawks, Argirios Skulikidis, Meredith Akerman, Muhammad Wahdan Naseeb, Nicholas Scelzi, Parker Meeks, Reanay Berezovskiy

Category Research

Concept Venous Thromboembolism

Concept Liver Disease

Concept VTE Risk Factors

Concept Demographic Factor

Concept Laboratory Abnormality

Distinguished Non-Finalist

Presenter Organization Department of Internal Medicine, New York Institute of Technology College of Osteopathic Medicine at Arkansas State University, Jonesboro, AR 72401

Presenting Author Parker Meeks

Track Outcomes Research

Keywords

venous thromboembolism

liver disease

risk factors

thromboprophylaxis

MELD-Na

creatinine

platelet count

INR

malignancy

sepsis

Venous Thromboembolism

Liver Disease

VTE Risk Factors

Demographic Factor

Laboratory Abnormality