SHM Converge Scientific Abstract ePoster Gallery-Post-Discharge Outcomes in Patients on Anticoagulation at the Time of Major Trauma

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This retrospective Mayo Clinic study examined 1,056 trauma patients who were taking anticoagulants at hospital admission between 2012 and 2021. The researchers compared outcomes for patients discharged on anticoagulation versus those discharged without it, with follow-up extending to one year after discharge.<br /><br />The patient population was elderly overall (mean age 77.4 years), with 55% male and 45% female patients. Warfarin was the most common anticoagulant, and atrial fibrillation was the leading indication for therapy. Nearly half of the patients (46.9%) did not leave the hospital on anticoagulation despite having an indication for it.<br /><br />Key findings showed no significant difference in overall major bleeding after discharge between the anticoagulation and no-anticoagulation groups. However, the no-anticoagulation group had a significantly higher rate of intracranial bleeding than those discharged on anticoagulation. Most importantly, patients discharged on anticoagulation had significantly fewer cerebrovascular events (CVA/TIA) within one year compared with those discharged off anticoagulation. Readmission rates, including trauma-related readmissions, were similar between groups.<br /><br />The authors concluded that deciding whether to continue or stop anticoagulation after trauma is complex. Their findings suggest that restarting anticoagulation may reduce thromboembolic risk without clearly increasing overall major bleeding risk, though more data—especially on direct oral anticoagulants (DOACs)—are needed to guide clinical decision-making after traumatic injury.

Asset Subtitle

Eileen M. Russell

Meta Tag

Author List Eileen M. Russell, Karen M. Fischer, Max Guarda, Renu Bhargavi Boyapati, Robert D. McBane, Sandeep R. Pagali

Category Research

Concept Trauma Patient

Concept Anticoagulation

Concept Major Bleeding

Concept Post-Trauma Anticoagulation Decision

Concept Retrospective Study Design

Distinguished Non-Finalist

Presenter Organization Mayo Clinic

Presenting Author Eileen M. Russell

Track Outcomes Research

Keywords

trauma patients

anticoagulation

Mayo Clinic study

major bleeding

intracranial bleeding

cerebrovascular events

CVA/TIA

warfarin

atrial fibrillation

direct oral anticoagulants

Trauma Patient

Anticoagulation

Major Bleeding

Post-Trauma Anticoagulation Decision

Retrospective Study Design