SHM Converge Scientific Abstract ePoster Gallery-Omeprazole Associated Exercised Induced Hypertension

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This document describes a 52-year-old man with chronic GERD who was taking omeprazole long term and later developed exertional chest discomfort and abnormal blood pressure responses during exercise. Initial workup found no ischemic ST-segment changes, but his systolic blood pressure rose dramatically to 210 mmHg during stress testing, and he was diagnosed with exercise-induced hypertension. Treatment with amlodipine offered little relief.<br /><br />Several months later, he stopped omeprazole because of gastrointestinal side effects. Within two weeks, his exertional symptoms resolved. He also discontinued amlodipine, and repeat stress testing showed improved exercise tolerance and a lower peak blood pressure of 160 mmHg. Clinicians concluded that omeprazole likely contributed to his elevated exertional blood pressure and symptoms. He was switched to famotidine for GERD control.<br /><br />The document places this case in the context of prior research suggesting that proton pump inhibitors (PPIs) may impair vascular nitric oxide activity, disrupt redox biology, and possibly increase cardiovascular risk, especially in patients with coronary artery disease or unrecognized cardiovascular disease. It notes that the true prevalence of this effect is unknown but may be underappreciated because PPIs are so widely prescribed.<br /><br />Overall, the key message is that medications often considered low-risk, such as PPIs, may have important cardiovascular consequences in some patients. The authors recommend considering alternative GERD therapies in patients with hypertension or coronary artery disease and emphasize careful medication review when evaluating new cardiovascular symptoms.

Asset Subtitle

Kayla Hernandez

Meta Tag

Author List Cliff Reeber, Emma Weiland, Jennifer Trube, Kayla Hernandez, Sophia Elortegui

Category Clinical Vignettes

Concept Proton Pump Inhibitor

Concept Cardiac Risk

Concept Exercise-Induced Hypertension

Concept Exertional Symptom

Concept Famotidine

Distinguished Non-Finalist

Presenter Organization Lakeland Regional Health

Presenting Author Kayla Hernandez

Track Adult

Keywords

omeprazole

proton pump inhibitors

exercise-induced hypertension

exertional chest discomfort

blood pressure response

amlodipine

famotidine

gastroesophageal reflux disease

vascular nitric oxide

cardiovascular risk

Proton Pump Inhibitor

Cardiac Risk

Exercise-Induced Hypertension

Exertional Symptom

Famotidine