SHM Converge Scientific Abstract ePoster Gallery-Neuroleukemiosis: A Rare Presentation of Acute Myloid Leukemia

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This text describes a rare presentation of acute myeloid leukemia (AML) involving neuroleukemiosis, where leukemic cells infiltrate peripheral nerves or nearby soft tissues and can cause spinal cord compression and focal neurological deficits. Because this condition is uncommon, there are no established guidelines for diagnosis or treatment.<br /><br />The document suggests that MRI is a useful first step to identify infiltrative soft tissue masses around the spine, and PET imaging may also show FDG uptake in affected areas. In the reported case, thoracic and lumbar MRI scans revealed extensive paraspinal and lumbosacral soft tissue masses. A biopsy is needed to confirm the diagnosis.<br /><br />For management, the oncologists recommended fractional radiation therapy followed by induction chemotherapy. This treatment approach resolved both the neurological symptoms caused by spinal cord compression and the AML blast crisis. The text emphasizes that recognizing this unusual manifestation of AML is important because timely imaging, biopsy, and combined oncologic treatment can lead to improvement.

Asset Subtitle

Mathew A. Thomas

Meta Tag

Author List Dhruv Joshi, Mathew A. Thomas, Vijay Kata

Category Clinical Vignettes

Concept Neuroleukemiosis

Concept Spinal leukemic infiltration

Concept Acute Myeloid Leukemia

Concept Spinal Cord Compression

Concept Biopsy

Distinguished Non-Finalist

Presenter Organization Riverside Medical Center

Presenting Author Mathew A. Thomas

Track Adult

Keywords

acute myeloid leukemia

AML

neuroleukemiosis

spinal cord compression

peripheral nerve infiltration

MRI

PET imaging

paraspinal soft tissue masses

biopsy

radiation therapy

Neuroleukemiosis

Spinal leukemic infiltration

Acute Myeloid Leukemia

Spinal Cord Compression

Biopsy