SHM Converge Scientific Abstract ePoster Gallery-Jc Virus Encephalitis Without Progressive Multifocal Leukoencephalopathy: A Rare Presentation

Jc Virus Encephalitis Without Progressive Multifocal Leukoencephalopathy: A Rare Presentation

Pdf Summary

This abstract discusses JC virus (JCV), a polyomavirus best known for causing progressive multifocal leukoencephalopathy (PML) in immunocompromised patients. The case described is unusual because the patient had a single sub-centimeter subcortical lesion that remained stable across multiple MRI scans, without the typical clinical or imaging features of PML. This presentation is atypical for standard JCV-related disease.<br /><br />The summary emphasizes the importance of monitoring JCV DNA in cerebrospinal fluid (CSF), as it is crucial for evaluating treatment response in patients with suspected or confirmed JCV infection. It also notes that virus-specific T-cell therapy has not yet demonstrated clear clinical benefit, highlighting the need for further research and more data to determine its effectiveness.<br /><br />Overall, the document underscores that JCV disease can present outside the classic PML pattern and that CSF viral load tracking remains an important tool in management.

Asset Subtitle

Muhammad Tayyeb

Meta Tag

Author List Anosh A. Khan, Doantrang Du, Muhammad Tayyeb, Seemab Fatima

Category Clinical Vignettes

Concept JC Virus

Concept Progressive Multifocal Leukoencephalopathy

Concept Immunocompromised State

Concept Magnetic Resonance Imaging

Concept JC Virus DNA

Distinguished Non-Finalist

Presenter Organization Monmouth Medical Center

Presenting Author Muhammad Tayyeb

Track Adult

Keywords

JC virus

JCV

progressive multifocal leukoencephalopathy

PML

cerebrospinal fluid

CSF viral load

subcortical lesion

MRI scans

virus-specific T-cell therapy

immunocompromised patients

JC Virus

Progressive Multifocal Leukoencephalopathy

Immunocompromised State

Magnetic Resonance Imaging

JC Virus DNA