SHM Converge Scientific Abstract ePoster Gallery-In-Hospital Outcomes and Sex Differences in Septic Heart Failure Patients

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This study examined in-hospital outcomes and sex differences among septic patients with preexisting heart failure, comparing heart failure with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). The HFrEF group had significantly worse outcomes than the HFpEF group, including higher mortality (14.1% vs 10.1%), cardiac arrest, cardiogenic shock, inotrope use, ventricular arrhythmias, acute kidney injury, mechanical circulatory support use, and major complications. HFrEF patients also generated higher total hospital charges ($141,960 vs $118,101).  <br /><br />Some outcomes did not differ significantly, including respiratory failure, mechanical intubation, cerebrovascular accident, and length of stay. Pacemaker implantation was slightly lower in HFrEF, while PCI and mechanical circulatory support use were higher.  <br /><br />Independent predictors of mortality in both groups included a prior history of stroke and liver disease.  <br /><br />Sex-based analysis showed that male patients had worse outcomes in both the HFrEF and HFpEF subgroups. In contrast, female patients with HFrEF had higher rates of cerebrovascular accident.  <br /><br />Overall, the findings suggest that sepsis in patients with HFrEF is associated with greater in-hospital morbidity, mortality, and cost than in HFpEF, and that male sex may confer additional risk.

Asset Subtitle

Betina Sinanova

Meta Tag

Author List Akanimo Antia, Betina Sinanova

Category Research

Concept Heart Failure with Preserved Ejection Fraction

Concept Heart Failure with Reduced Ejection Fraction

Concept Sepsis

Concept Inpatient Mortality

Concept Shock

Distinguished Non-Finalist

Presenter Organization Lincoln Medical Center

Presenting Author Betina Sinanova

Track Outcomes Research

Keywords

sepsis

heart failure

HFpEF

HFrEF

in-hospital mortality

sex differences

cardiogenic shock

acute kidney injury

ventricular arrhythmias

hospital charges

Heart Failure with Preserved Ejection Fraction

Heart Failure with Reduced Ejection Fraction

Sepsis

Inpatient Mortality

Shock