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Fulminant Myocarditis Related to Influenza Virus
Fulminant Myocarditis Related to Influenza Virus
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This case report describes a 41-year-old man with hypertension who presented with six days of flu-like illness and worsening shortness of breath. On arrival, he was hypertensive, tachycardic, diaphoretic, and appeared critically ill. Initial labs showed leukocytosis, acute kidney injury, elevated lactate, and markedly increased troponin. ECG demonstrated a left bundle branch block of unclear chronicity.<br /><br />His condition deteriorated rapidly into pulseless electrical activity arrest, requiring CPR and ICU admission with vasopressor and ventilatory support. Repeat ECG showed ST elevation, and CT imaging revealed extensive thrombosis involving the left ventricle, inferior vena cava, and iliac vein, along with renal infarcts. Echocardiography showed severe biventricular dysfunction with an ejection fraction of 10%, consistent with fulminant myocarditis and cardiogenic shock.<br /><br />He was started on heparin and underwent emergent cardiac catheterization, which showed no obstructive coronary artery disease. An intra-aortic balloon pump was placed, and he was transferred for possible VA-ECMO. Over the following days, he received supportive care for suspected influenza-related myocarditis and improved significantly. He was eventually extubated, the balloon pump was removed, and guideline-directed medical therapy was started.<br /><br />The report emphasizes that influenza can rarely cause fulminant myocarditis, especially in young males, and may progress quickly to shock, cardiac arrest, and thromboembolic complications. Early recognition, mechanical circulatory support, and supportive management are critical and can lead to recovery.
Asset Subtitle
Harpreet Gosal
Meta Tag
Author List
Clark McDonough, Harpreet Gosal
Category
Clinical Vignettes
Concept
Fulminant Myocarditis
Concept
Left Ventricular Dysfunction
Concept
Cardiogenic Shock
Concept
Influenza Infection
Concept
Intracardiac Thrombus
Distinguished
Non-Finalist
Presenter Organization
Hamilton Medical Center
Presenting Author
Harpreet Gosal
Track
Adult
Keywords
fulminant myocarditis
influenza myocarditis
cardiogenic shock
pulseless electrical activity
thromboembolism
left ventricular thrombosis
intra-aortic balloon pump
VA-ECMO
acute kidney injury
biventricular dysfunction
Fulminant Myocarditis
Left Ventricular Dysfunction
Cardiogenic Shock
Influenza Infection
Intracardiac Thrombus
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