SHM Converge Scientific Abstract ePoster Gallery-Effect of Anticoagulants and Steroids on Covid Outcomes: International Study

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This international retrospective cohort study compared COVID-19 outcomes in two healthcare settings: the University of Minnesota (UMN) in the United States and multiple hospitals in Cairo, Egypt. The study included 4,278 patients treated between March 1 and May 31, 2020, and examined whether differences in treatment strategies—especially corticosteroids (CCS) and anticoagulant therapy (ACT)—affected in-hospital mortality.<br /><br />The cohorts differed in case mix and treatment practices. US hospitals generally admitted more severe COVID-19 cases, while Egyptian hospitals admitted a broader range of symptomatic, COVID-positive patients under national management protocols. Researchers analyzed demographics, comorbidities, ICU admission, ACT, CCS, and mortality using chi-square/Fisher’s exact tests and multivariable regression.<br /><br />Key findings showed that mortality increased with older age, male sex, and ICU admission in both cohorts. In the Egyptian cohort, both anticoagulation and corticosteroid use were associated with significantly lower mortality. Specifically, age 75+, ICU admission, and male sex increased mortality, while ACT and CCS reduced it. In the UMN cohort, age 75+, male sex, and ICU admission also increased mortality, while hypertension was associated with lower mortality; anticoagulation showed a trend toward reduced mortality but did not reach statistical significance.<br /><br />Overall, the study concluded that both cohorts shared similar risk factors for death, but the Egyptian cohort showed reduced mortality with CCS and ACT, consistent with clinical trial evidence. Differences in the US cohort may have been due to lower event rates.

Asset Subtitle

Atharva Dhole

Meta Tag

Author List Ahmed Abdelhalim Mohamed, Ahmed Elgebaly, Ahmed Heiba, Atharva Dhole, Bassem Eysa, Dalia Omran, Eshak I. Bahbah, Hend Shousha, Katelyn Tessier, Lamiaa Kamal, Mahmoud Khalil, Muhammad Mostafa Abdelghafar, Sameh Hozayen, Sarah Alabsi, Scott A. Chapman,

Category Research

Concept COVID-19 Mortality

Concept Inpatient Mortality

Concept Age

Concept Intensive Care Unit Admission

Concept Comorbidity

Distinguished Non-Finalist

Presenter Organization University of Minnesota

Presenting Author Atharva Dhole

Track Outcomes Research

Keywords

COVID-19

retrospective cohort study

mortality

corticosteroids

anticoagulant therapy

University of Minnesota

Cairo hospitals

ICU admission

risk factors

Egyptian cohort

COVID-19 Mortality

Inpatient Mortality

Age

Intensive Care Unit Admission

Comorbidity