SHM Converge Scientific Abstract ePoster Gallery-Does Obesity Paradox Hold True for Clostridium Difficile Infection? A National Inpatient Database Analysis

Does Obesity Paradox Hold True for Clostridium Difficile Infection? A National Inpatient Database Analysis

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This 2016 National Inpatient Sample study examined whether obesity is associated with lower in-hospital mortality among adults hospitalized with Clostridium difficile infection (CDI), as part of testing the “obesity paradox.”<br /><br />Using ICD-10 codes, the authors identified 89,649 CDI hospitalizations, including 7,785 obese patients and 81,864 non-obese patients, excluding patients with malnutrition. They compared mortality and adjusted for multiple factors such as age, sex, race, Charlson comorbidity index, hospital characteristics, and several CDI-related complications and comorbidities.<br /><br />Key findings:<br />- Obese patients were more often female, slightly younger, and had slightly longer stays and higher hospital charges than non-obese patients.<br />- Unadjusted mortality was lower in obese patients, but this difference was not statistically significant (OR 0.71, 95% CI 0.38–1.33, p = 0.294).<br />- After multivariable adjustment, the association remained non-significant (OR 0.79, 95% CI 0.41–1.53, p = 0.499).<br /><br />Conclusion:<br />The study did not find evidence that obesity reduces in-hospital mortality in CDI. Therefore, it does not support an obesity paradox for Clostridium difficile infection. The authors suggest that larger studies are needed to better understand the relationship between obesity and CDI outcomes.

Asset Subtitle

Vinaya Jaikumar

Meta Tag

Author List Ansu Karki, Riddhima Naik, Samir Jha, Vinaya Jaikumar

Category Research

Concept Obesity Paradox

Concept Clostridioides difficile Infection

Concept Inpatient Mortality

Concept Odds Ratio

Concept Obesity

Distinguished Non-Finalist

Presenter Organization Bassett Medical Center

Presenting Author Vinaya Jaikumar

Track Outcomes Research

Keywords

obesity paradox

Clostridium difficile infection

CDI mortality

in-hospital mortality

National Inpatient Sample

ICD-10 codes

obesity

multivariable adjustment

hospitalization outcomes

Charlson comorbidity index

Obesity Paradox

Clostridioides difficile Infection

Inpatient Mortality

Odds Ratio

Obesity