SHM Converge Scientific Abstract ePoster Gallery-Clinical Outcomes of Patients With Diabetic Ketoacidosis and Acute Pancreatitis

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This retrospective cross-sectional comparative study examined adult patients admitted with diabetic ketoacidosis (DKA) between 2015 and 2021, comparing those with concurrent acute pancreatitis (DKA+AP) to those with DKA alone. The cohort included 936 patients overall: 84 with DKA+AP and 852 with DKA only.<br /><br />Patients with DKA+AP were older on average (42.7 vs 35.3 years), more likely to be Asian (65.5%), and more often had type 2 diabetes (75%). Compared with DKA alone, the DKA+AP group showed more severe biochemical abnormalities, including lower pH, higher anion gap, higher neutrophil-to-lymphocyte ratio, higher creatinine, and higher triglyceride and cholesterol levels. These findings suggest greater metabolic derangement, inflammation, and kidney injury in the combined condition.<br /><br />Clinically, patients with DKA+AP had worse outcomes than those with DKA alone, including longer duration of DKA, longer hospital length of stay, and more frequent ICU admission. Mortality was also assessed as an outcome.<br /><br />Univariate analysis identified several factors associated with DKA+AP, including older age, Asian ethnicity, male sex, type 2 diabetes, higher white blood cell count, higher creatinine, lower pH, higher anion gap, and elevated triglycerides, LDL, and cholesterol. In multivariate analysis, age and total cholesterol remained significant factors.<br /><br />Overall, the study concluded that concurrent acute pancreatitis in patients with DKA is associated with more severe laboratory abnormalities and poorer clinical outcomes, including prolonged hospitalization and greater ICU use, compared with DKA alone.

Asset Subtitle

Anand Kartha

Meta Tag

Author List Adeel Ahmad Khan, Ahmad Matarneh, Anand Kartha, Bassam M. Muthanna, Bassel Dakkak, Fateen Ata, Malik Halabiya, Mohamad Safwan Aljafar, Mohammed Najdat Seijari, Zohaib Yousaf

Category Research

Concept Diabetic Ketoacidosis

Concept Acute Pancreatitis

Concept Length of Stay

Concept Intensive Care Unit Admission

Concept Mortality

Distinguished Non-Finalist

Presenter Organization Hamad Medical Corporation, Weill Cornell Medicine-Qatar

Presenting Author Anand Kartha

Track Outcomes Research

Keywords

diabetic ketoacidosis

acute pancreatitis

DKA+AP

cross-sectional study

type 2 diabetes

anion gap

triglycerides

hospital length of stay

ICU admission

mortality

Diabetic Ketoacidosis

Acute Pancreatitis

Length of Stay

Intensive Care Unit Admission

Mortality