SHM Converge Scientific Abstract ePoster Gallery-Chest Ct Lung Involvement on Admission and Outcomes in Sars-Cov-2 Hospitalizations

Chest Ct Lung Involvement on Admission and Outcomes in Sars-Cov-2 Hospitalizations - A Systemic Review and Meta-Analysis

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This systematic review and meta-analysis evaluated whether bilateral multiple lobular lung involvement on admission chest CT scans predicts worse outcomes in hospitalized COVID-19 patients. The authors searched PubMed, Web of Science, and Scopus for English-language observational studies published from January 1 to December 30, 2020, following PRISMA guidelines. Poor outcomes were defined as ICU admission, SpO2 <90%, invasive mechanical ventilation, severe disease, or in-hospital mortality. CT findings included bilateral lobular abnormalities such as ground-glass opacities, consolidation, crazy-paving, air bronchogram, linear opacities, bronchial wall thickening, and pleural effusion.<br /><br />Twelve studies involving 3,485 confirmed COVID-19 patients were included. Bilateral multiple lobular involvement on admission CT was more common among patients with poor outcomes than among those with non-poor outcomes (75.95% vs 60.95%, p<0.00001). Meta-analysis using a random-effects model showed that patients with bilateral multiple lobular lung involvement had 2.54 times higher odds of poor composite outcomes (95% CI: 1.81–3.38, p<0.00001), with low-to-moderate heterogeneity.<br /><br />The study concludes that bilateral multiple lobular lung involvement on admission chest CT is significantly associated with worse clinical outcomes in hospitalized COVID-19 patients. This imaging finding may help clinicians with early risk stratification, prognosis, and planning of care. The authors recommend further prospective cohort studies to better clarify this association and improve proactive management.

Asset Subtitle

Vrushali Shelar

Meta Tag

Author List Amit M. Sharma, George Varghese, Manoj Tanwar, Mitulkumar Patel, Nitesh K. Jain, Richa Jaiswal, Rutikbhai Desai, Sankeerth Thoota, Teresa Varghese, Thoyaja Koritala, Vrushali Shelar

Category Research

Concept COVID-19

Concept Bilateral Involvement

Concept Chest Computed Tomography

Concept Meta-Analysis

Concept Odds Ratio

Distinguished Non-Finalist

Presenter Organization Saratov State Medical University, Russia

Presenting Author Vrushali Shelar

Track Outcomes Research

Keywords

COVID-19

chest CT

bilateral lobular involvement

poor outcomes

meta-analysis

systematic review

hospitalized patients

ground-glass opacities

risk stratification

prognosis

COVID-19

Bilateral Involvement

Chest Computed Tomography

Meta-Analysis

Odds Ratio