SHM Converge Scientific Abstract ePoster Gallery-Cardiovascular Death or Hospitalization Risk With Sglt2i in Heart Failure

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This umbrella analysis evaluated whether SGLT-2 inhibitors reduce the risk of cardiovascular death or hospitalization for heart failure in patients with heart failure. The authors noted that while several meta-analyses already suggested benefit, it was unclear whether those reviews included all relevant primary studies.<br /><br />Nine systematic reviews/meta-analyses were included, and the authors assessed their quality using the AMSTAR 2 tool. They found overlap among the primary studies, but no single review contained all available studies. Using an inverse-variance pooled analysis in RevMan, they found that SGLT-2 inhibitors significantly reduced the composite outcome of cardiovascular death or hospitalization for heart failure compared with control. Reported reductions ranged from 21% to 30%, and the pooled estimate showed a 24% relative risk reduction overall (HR 0.76; 95% CI 0.74–0.78; p = 0.01; I² = 0%).<br /><br />The conclusion was that SGLT-2 inhibitors provide substantial benefit in heart failure, especially in reducing major hospital-related cardiovascular outcomes. The authors reported no financial disclosures.

Asset Subtitle

Tirath Daishikbhai Patel

Meta Tag

Author List Advait Vasavada, Dakshin Meenashi Sundaram, Nosheen Hafeez, Raj Roy, Rishabh Baskara Salian, Saketh Vinjamuri, Tirath Daishikbhai Patel

Category Research

Concept SGLT-2 Inhibitors

Concept Heart Failure

Concept Heart Failure Hospitalization

Concept Circulatory Death

Concept Meta-Analysis

Distinguished Non-Finalist

Presenter Organization American University of Antigua, St. John, ATG

Presenting Author Tirath Daishikbhai Patel

Track Education

Keywords

SGLT-2 inhibitors

heart failure

cardiovascular death

hospitalization

systematic review

meta-analysis

AMSTAR 2

RevMan

relative risk reduction

clinical outcomes

SGLT-2 Inhibitors

Heart Failure

Heart Failure Hospitalization

Circulatory Death

Meta-Analysis