SHM Converge Scientific Abstract ePoster Gallery-Calcinosis Universalis Secondary to Silicone Injections in a Patient With Hiv and Chronic Kidney Disease: A Case Report of Silicone-Induced Hypercalcemia

Calcinosis Universalis Secondary to Silicone Injections in a Patient With Hiv and Chronic Kidney Disease: A Case Report of Silicone-Induced Hypercalcemia

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This case report describes a 44-year-old African American man with HIV and chronic kidney disease who presented with headache, gait imbalance, and flank pain. Laboratory testing showed moderate hypercalcemia with acute kidney injury and an inappropriately normal parathyroid hormone level, suggesting a non-parathyroid cause of hypercalcemia. CT imaging revealed bilateral hyperlucent/calcified deposits in the gluteal region, and the patient later disclosed a history of silicone injections performed about 20 years earlier.<br /><br />He was initially treated with intravenous fluids and pamidronate, which temporarily normalized his calcium levels. However, he was readmitted one month later with recurrent hypercalcemia. Because of his chronic kidney disease, nephrology recommended denosumab rather than additional bisphosphonates. After one dose, his calcium improved, though he was eventually lost to follow-up before completing treatment.<br /><br />The report emphasizes that calcinosis universalis secondary to silicone injections is a rare but important cause of hypercalcemia, especially as cosmetic procedures become more common. Clinicians should consider this diagnosis in patients with unexplained hypercalcemia and a history of cosmetic injections or foreign material exposure. Early recognition is important to guide proper treatment and prevent complications.

Asset Subtitle

Juan D. Sarmiento

Meta Tag

Author List Juan D. Sarmiento, Micaela Mayer, Rachel Reise

Category Clinical Vignettes

Concept Calcinosis Universalis

Concept Hypercalcemia

Concept Silicone-Induced Granulomatous Disease

Concept Cosmetic Silicone Injection

Concept Parathyroid Hormone

Distinguished Non-Finalist

Presenter Organization University of Florida

Presenting Author Juan D. Sarmiento

Track Adult

Keywords

hypercalcemia

calcinosis universalis

silicone injections

acute kidney injury

chronic kidney disease

HIV

parathyroid hormone

pamidronate

denosumab

foreign material exposure

Calcinosis Universalis

Hypercalcemia

Silicone-Induced Granulomatous Disease

Cosmetic Silicone Injection

Parathyroid Hormone