SHM Converge Scientific Abstract ePoster Gallery-An Unusual Cause of Hypereosinophilia After Ascending Aortic Aneurysm Repair

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This case report describes a 73-year-old woman who developed hypereosinophilia after ascending aortic aneurysm repair with hemi-arch replacement. One month after surgery, she was evaluated for low blood pressure and found incidentally to have an elevated absolute eosinophil count (AEC) of 1,800/µL, along with thrombocytosis and mild leukocytosis. Her eosinophil count continued to rise, peaking at 4,500/µL.<br /><br />A broad evaluation for common causes of hypereosinophilia—including medication reaction, travel-related infection, hematologic disease, rheumatologic disease, and other systemic illness—was unrevealing. She had no symptoms or evidence of end-organ damage, and her eosinophilia eventually resolved spontaneously.<br /><br />After the initial workup failed to identify a cause, clinicians revisited her recent surgery. During the operation, she had received TachoSil, a topical fibrin sealant patch. Post-marketing data have linked TachoSil to eosinophilia, and the timing of exposure matched the patient’s laboratory abnormalities. TachoSil was therefore determined to be the likely cause of her hypereosinophilia.<br /><br />The report emphasizes that hypereosinophilia, defined as an AEC of at least 1,500/µL, can lead to serious tissue infiltration and organ damage even when asymptomatic. It also highlights the importance of considering surgical grafts and implants, not just medications and supplements, in the differential diagnosis of unexplained eosinophilia.

Asset Subtitle

Lana Bridi

Meta Tag

Author List Andrew Kao, Lana Bridi, Sean Kenmore, Sukhdeep Khurana

Category Clinical Vignettes

Concept Hypereosinophilia

Concept Organ damage

Concept Drug-Induced Hypereosinophilia

Concept Temporal Association

Concept Diagnostic Workup

Distinguished Non-Finalist

Presenter Organization UC San Diego Health Center

Presenting Author Lana Bridi

Track Adult

Keywords

hypereosinophilia

eosinophilia

TachoSil

ascending aortic aneurysm repair

hemi-arch replacement

fibrin sealant patch

absolute eosinophil count

thrombocytosis

postoperative complication

case report

Hypereosinophilia

Organ damage

Drug-Induced Hypereosinophilia

Temporal Association

Diagnostic Workup