SHM Converge Scientific Abstract ePoster Gallery-Acute Kidney Injury and 30-Day Hospital Readmission Rate in Cancer Patients With Glomerular Filtration Rate

Acute Kidney Injury and 30-Day Hospital Readmission Rate in Cancer Patients With Glomerular Filtration Rate > 60 and Acquired Covid-19

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This retrospective study evaluated 635 adult cancer patients at a tertiary cancer center who had baseline eGFR ≥60 ml/min/1.73 m² and acquired COVID-19 infection. The researchers examined whether acute kidney injury (AKI), defined as a serum creatinine rise of at least 0.3 mg/dl within 30 days of a positive COVID-19 test, was associated with 30-day hospital readmission and worse outcomes.<br /><br />AKI developed in 124 patients (19.5%) within 30 days of COVID-19 diagnosis. Compared with patients without AKI, those with AKI were older and had higher rates of hypertension, cardiac arrhythmias, pneumonia, and myocardial infarction. They also had more severe clinical courses, including greater need for dialysis at 30 days (2.4% vs 0.2%), intensive care management (43.5% vs 11.5%), and mechanical ventilation (16.1% vs 1.8%). Ninety-day mortality was also substantially higher in the AKI group (20.2% vs 3.7%).<br /><br />The 30-day readmission rate was significantly higher among patients who developed AKI after COVID-19 infection (71% vs 47.4%, p<0.001). In multivariate Cox proportional hazard analysis, diabetes mellitus emerged as an independent risk factor for worse clinical outcomes (HR 10.8, 95% CI 2.42–48.4, p<0.001).<br /><br />Overall, the study shows that in hospitalized cancer patients with COVID-19, AKI is common and strongly associated with higher readmission, greater need for critical care, and increased mortality. The findings emphasize the importance of preventing AKI through careful monitoring, early intervention, and medical optimization during hospitalization.

Asset Subtitle

Cesar Simbaqueba Clavijo

Meta Tag

Author List Cesar Simbaqueba Clavijo, Kodwo Bosomefi Dickson, Maria Franco Vega, Omar Mamlouk, Sreedhar Mandayam

Category Research

Concept Acute Kidney Injury

Concept 30-day Hospital Readmission

Concept Oncology Patient

Concept COVID-19

Concept Dialysis

Distinguished Non-Finalist

Presenter Organization The University of Texas MD Anderson Cancer Center

Presenting Author Cesar Simbaqueba Clavijo

Track Outcomes Research

Keywords

acute kidney injury

COVID-19

cancer patients

hospital readmission

mortality

dialysis

intensive care

mechanical ventilation

diabetes mellitus

retrospective study

Acute Kidney Injury

30-day Hospital Readmission

Oncology Patient

COVID-19

Dialysis