SHM Converge Scientific Abstract ePoster Gallery-Acute Ischemic Stroke: Considering All the Factors

Pdf Summary

The document gives guidance on thrombophilia testing in young stroke patients. It states that inpatient screening can and should be done for common thrombophilias such as Factor V Leiden, which may increase the risk of arterial thromboembolism.<br /><br />Key points:<br />- Some thrombophilia tests are not affected by the acute phase of thrombosis or by anticoagulant therapy. These include:<br />  - Factor V Leiden mutation<br />  - Prothrombin gene mutation<br />  - Anticardiolipin antibodies<br />  - Anti-beta-2 glycoprotein antibodies<br />- Some tests may be inaccurate during the acute phase of thrombosis:<br />  - Protein C deficiency<br />  - Protein S deficiency<br />  - Antithrombin mutation<br />- Some tests may be affected by anticoagulant use:<br />  - Protein C deficiency<br />  - Protein S deficiency<br />  - Antithrombin mutation<br />  - Lupus anticoagulant<br /><br />Testing timing recommendation:<br />- Inpatient: Factor V Leiden mutation, Prothrombin gene mutation, Anticardiolipin antibody, Anti-beta-2 glycoprotein antibody<br />- Outpatient: Protein C and S deficiency testing, Antithrombin mutation testing, Lupus anticoagulant testing<br /><br />Overall, the document emphasizes that certain inherited thrombophilia tests can be safely and accurately ordered during hospitalization, while others should be deferred to outpatient follow-up because acute thrombosis or anticoagulation can distort results.

Asset Subtitle

Shripadh S. Chitta

Meta Tag

Author List Benjamin M. Goodman, Kanishk D. Sharma, Nicholas Kochakian, Shripadh S. Chitta

Category Clinical Vignettes

Concept Thrombophilia Testing

Concept Acute Thrombosis

Concept Anticoagulation Therapy

Concept Inpatient Screening

Concept Young Stroke

Distinguished Non-Finalist

Presenter Organization EVMS Department of Internal Medicine

Presenting Author Shripadh S. Chitta

Track Adult

Keywords

thrombophilia testing

young stroke

Factor V Leiden

prothrombin gene mutation

anticardiolipin antibodies

anti-beta-2 glycoprotein antibodies

protein C deficiency

protein S deficiency

antithrombin mutation

lupus anticoagulant

Thrombophilia Testing

Acute Thrombosis

Anticoagulation Therapy

Inpatient Screening

Young Stroke