SHM Converge Scientific Abstract ePoster Gallery-Acute Hypoxic Respiratory Failure in the Setting of Hypertrophic Cardiomyopathy

Pdf Summary

This document describes a mechanism of <strong>hypoxemic shock caused by an intracardiac Venturi effect</strong>, particularly in the setting of <strong>gastrointestinal bleeding</strong>. The proposed pathophysiology is:

1. <strong>GI bleed leads to reduced preload</strong>
2. Reduced preload causes <strong>decreased left ventricular (LV) size</strong>
3. A smaller LV increases the <strong>Venturi effect</strong>
4. This promotes <strong>systolic anterior motion (SAM)</strong> of the mitral valve
5. SAM results in <strong>functional mitral regurgitation</strong>
6. The combination can contribute to <strong>hypoxemic shock</strong>

The topic is closely related to <strong>hypertrophic cardiomyopathy (HCM)</strong> and dynamic left ventricular outflow tract obstruction, where decreased ventricular filling can worsen obstruction and valvular dysfunction. The cited references include major cardiology guidelines and review sources on HCM and SAM, emphasizing the clinical relevance of recognizing preload-dependent hemodynamic collapse.

In short, the document highlights that <strong>volume depletion from bleeding can trigger a cascade of intracardiac flow abnormalities</strong>, leading to severe shock and oxygenation impairment, especially in patients predisposed to dynamic LV outflow obstruction.

Asset Subtitle

Alexandra Malesz

Meta Tag

Author List Alexandra Malesz, Ran Ran

Category Clinical Vignettes

Concept Preload

Concept Systolic anterior motion

Concept Functional mitral regurgitation

Concept Left Ventricular Outflow Tract Obstruction

Concept Venturi effect

Distinguished Non-Finalist

Presenter Organization Ohsu

Presenting Author Alexandra Malesz

Track Adult

Keywords

hypoxemic shock

intracardiac Venturi effect

gastrointestinal bleeding

reduced preload

systolic anterior motion

functional mitral regurgitation

hypertrophic cardiomyopathy

left ventricular outflow tract obstruction

volume depletion

hemodynamic collapse

Preload

Systolic anterior motion

Functional mitral regurgitation

Left Ventricular Outflow Tract Obstruction

Venturi effect