SHM Converge Scientific Abstract ePoster Gallery-A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Intravenous Acetaminophen Use for Pain Management in Small Bowel Obstruction- Interim Analysis of Feasibility and Outcomes

A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Intravenous Acetaminophen Use for Pain Management in Small Bowel Obstruction- Interim Analysis of Feasibility and Outcomes

Back to course

Pdf Summary

This interim analysis reports a double-blind, randomized, placebo-controlled trial evaluating intravenous (IV) acetaminophen for pain management in small bowel obstruction (SBO). The study was conducted at Mayo Clinic Jacksonville from September 2023 to October 2024 and included 18 hospitalized patients managed non-surgically for SBO. Patients were assigned to IV acetaminophen or placebo, while both groups could also receive other analgesics such as morphine, hydromorphone, or ketorolac at the treating physician’s discretion.<br /><br />The primary goals were to assess feasibility and evaluate pain scores, opioid use, time to SBO resolution, length of stay, and 30-day mortality. Secondary outcomes included bowel perforation, surgical intervention, and adverse reactions. The two groups were similar at baseline in age, sex, ethnicity, SBO type and cause, prior abdominal surgery, inflammatory bowel disease, malignant SBO, NG tube use, and SBO resolution status.<br /><br />Results showed no statistically significant differences, but several trends favored IV acetaminophen. The treatment group had lower mean opioid use during the study (MME 9.1 vs. 17.3), lower pain scores on days 1 and 2, shorter length of stay (6.0 vs. 8.1 days), and faster SBO resolution (1.1 vs. 5.5 days), though these differences did not reach significance. One patient in the acetaminophen group required surgery, while one placebo patient required a venting tube. No bowel perforation, allergic reaction, delirium, or naloxone use occurred.<br /><br />The authors conclude that IV acetaminophen appears feasible and may improve pain control, reduce opioid exposure, and speed recovery in SBO, but larger enrollment is needed. The trial is ongoing and plans to recruit 40 patients through December 2026.

Asset Subtitle

Tatjana Gavrancic

Meta Tag

Author List Aleksandra Murawska-Baptista, Colt C. Cowdell, Igor Dumic, Jeniffer Cowart, Kathik Gnanapandithan, Michael J. Maniaci, Nancy Dawson, Ricardo Pagan, Tatjana Gavrancic, Waqas Tahir

Category Research

Concept Randomized Trial

Concept Small Bowel Obstruction

Concept Intravenous Acetaminophen

Concept Pain Control

Concept Double-Blind Trial

Distinguished Non-Finalist

Presenter Organization Mayo Clinic, Jacksonville, Florida

Presenting Author Tatjana Gavrancic

Track Outcomes Research

Keywords

intravenous acetaminophen

small bowel obstruction

randomized controlled trial

placebo-controlled trial

pain management

opioid use

Mayo Clinic Jacksonville

feasibility study

bowel obstruction resolution

hospitalized patients

Randomized Trial

Small Bowel Obstruction

Intravenous Acetaminophen

Pain Control

Double-Blind Trial